Ahmad Hussain

HussainDr. Ahmad Fawzi Hussain
University Hospital Aachen
Dep. of Gynecology and Obstetrics
Pauwelstr. 30
D-52074 Aachen
phone +49 241 6085 11462
email: ahmad.hussain@molbiotech.rwth-aachen.de

  Personal Information   

  • Date and place of Birth: 1st of Feb. 1976 in Baghdad
  • Gender: Male
  • Marital Status: Married
  • Nationality: Iraqi 
Education
  • ·         (2008-2012) PhD in Molecular Biology from RWTH-Aachen University, Institute of Applied medical Enginnering and Fraunhofer IME, Department of Pharmacotical Product Development  with a very good rating.
  • ·         (2002-2005) M. Sc. in Biotechnology  from  Al-Balqa’ Applied University (Jordan) in July 2005 with a very good rating.
  • ·         (1994-1998) B. Sc. in Microbiology from Al-Mustansiriyah University (Iraq) in July 1998 with a good rating. 
Professional Experience
  • ·         March 2013 – present, working as a senior scientist in the Department of Gynecology and Obstetrics, University Hospital Aachen
  • ·         July, 2012- March 2013, working as a senior scientist in RWTH-Aachen University, Institute of Applied medical Enginnering.
    • ·         Oktober, 2008-2012, PhD sutudent in RWTH-Aachen University, Institute of Applied medical Engineering and Fraunhofer Institute for Molecular Biology and Applied Ecology.
    • ·         Septembre, 2005- June 2008, working as a researcher in the project “Development of transgenic tomato plants resistant to Tomato   yellow leaf curl virus (TYLCV) via gene silencing technology”, which is supported by USAID and the Middle East Regional Cooperation Program (MERC). Al-Balqa’ Applied University/ Department of Biotechnology. 
    
Research
  • ·         Photoimmunotheronostics to detect and eliminate gynecological cancer cells
  • ·         Nanoimmunotheronostics to detect and eliminate cancer cells
  • ·         siRNA delivery against cancer cells.
    • ·           Antibody engineering for targeted tumor therapy. 
Publications
  • ·         Hussain, A. F., Krüger, H.R., Kampmeier, F., Weissbach, T., Licha, K., Kratz, F., Haag, R., Calderón, M., Barth, S. Targeted delivery of dendritic polyglycerol-doxorubicin conjugates by scFv-SNAP fusion protein suppresses EGFR+ cancer cell growth. Biomacromolecules, 2013. 14(8): p.2510-20.
    • ·         Hussain, A. F., Wullner, U., Neef, I., Tur, M.K. and Barth, S. Targeted delivery of short interfering RNAs – strategies for in vivo delivery. Book chapter in Topics in anti-cancer research book. Vol. 1, 2012, P. 228-253.
  • Hussain, A. F., Tur, M. T and Barth, S. An aptamer-siRNA chimera silences the eukaryotic elongation factor 2 gene and induces apoptosis in αvβ3 integrin expressing cancers. Nucleic Acid Therapeutics, 2013. 23(3): p. 203-12.
  • Hussain, A. F., Amoury, M. and Barth, S. SNAP-Tag Technology: A Powerful Tool for Site Specific Conjugation of Therapeutic and Imaging Agents. Current Pharmaceutical Design, 2013. 19(30): p5437-42.
  • Hussain, A. F., Kampmeier, F., von Felbert, V., Merk, H., Tur, M. T and Barth, S. SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells. Bioconjug Chem, 2011. 22(12): p. 2487-95.
  • Anfoka, G., Haj Ahmad, F., Abhary, M. and Hussein, A. F. Detection and molecular characterization of viruses associated with tomato yellow leaf curl disease in cucurbit crops in Jordan. Plant Pathology. Published Online: 2009. 5 Apr 2009.
  • Anfoka, G., Abhary, M., Haj Ahmad, F., and Hussein, A. F., Rezk, A., Akad, F. , Abou-Jawdah, Y., Lapidot, M., Vidavski, F., Nakhla, M. K. , Sobh, H. , Atamian, H., Cohen, L., Sobol, I. Mazyad, H., Maxwell, D. P. and Czosnek, H. Survey of Tomato Yellow Leaf Curl Disease-Associated Viruses In The Eastern Mediterranean Basin. Journal of Plant Pathology. 2008. 90: p311-320.
  • Hussain, A. F., Anfoka, G., and Hassawi, D. S. Transformation of Tomato with TYLCV Gene Silencing Constract Using Optimized Agrobacterium-Mediated Protocol. Biotechnology. 2008 7: p537-543.
 Patent
  • Hussain, A. F., Tur, M. T and Barth, S. Novel Photoimmunoconjugates for Use in Photodynamic Therapy. Submitted to the European Patent Office PCT/EP2012/055022.
Posters
  • ·         Hussain, A. F., Krüger, H. R., Bauerschlag, D., Maass, N., Calderón, M. and Barth, S. Targeted-nanocarrier drug delivery using scFv-SNAP tag fusion protein eliminates EGFR expressing cancer cells. Antibody Engineering & Therapeutics conference, Huntington Beach, CA, USA, 2013.  
  • ·         Hussain, A. F., Tur, M. T and Barth. Eliminating αvβ3 integrin expressing cancer cells specifically using an aptamer-siRNA chimera. Biomedica, Aachen, 2013.
  • ·         Tur M.K., Hussain A. F., Barth S. Disease-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing Eukaryotic Elongation factor 2, 29. Deutscher Krebskongress Berlin, Onkologie -International Journal for Cancer Research and Treatment-, Suppl. 2, Band 33, p153 (02/2010).
  • Hussain, A. F., Kampmeier, F., Tur, M. K., and Barth, B., Site-specific covalent conjugation of a photosensitizer to the recombinant antibody fragments improves the specific phototoxicity. Biomedica, Liège, 2012. 
Scholarships and prize
  • 2002-2008, awarded Master-study scholarship from the Ministry of Higher Education. Iraq.
  • ·         2008-2012, awarded PhD scholarship from the German academic exchange service (DAAD). Germany.
  • ·         2013, awarded Scholarship program for Antibody Engineering & Therapeutics conference, Huntington Beach, CA, USA, 2013.
Languages
  • ·                Arabic        (Mother Language)
  • ·                English       (Very Good)
  • ·                Germany   (Good)